0704-883-0675     |      dataprojectng@gmail.com

ANTIBACTERIAL ACTIVITY OF HELIANTHUS ANNUUS SEEDS EXTRACT ON SALMONELLA SPECIES AND ESCHERICHIA COLI

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 5000

ABSTRACT Medicinal plants contain active ingredients with therapeutic values. Helianthus annuus L (Asteraceae) commonly referred to as “sunflower” has been reportedly used in managing and treating some ailments over the years. This study investigated the in vitro and in vivo antibacterial effects of the crude extracts of Helianthus annuus seeds on Salmonella spp and Eschericha coli. The phytochemical screening of the methanolic and ethanolic crude extracts revealed the presence of alkaloids, saponins, tannins, flavonoids and phenols. The effect of the crude extracts against the test organisms ranges from 7.33±0.67 mm to 25.67±0.33 mm at concentrations ranging from 60 mg/ml to 480 mg/ml. The minimum inhibitory concentration of the extracts ranges from 0.07±0.03 mg/ml to 2.40±0.06 mg/ml. The minimum bactericidal concentration of the extracts ranges from 0.48±0.01 mg/ml to 2.40±0.12 mg/ml. The acute toxicity study revealed LD50>2000 mg/kg. The sub acute toxicity study showed that there was a significant decrease in Alanine transaminase, Aspartate transaminase and Alanine phosphatase levels in most of the treated groups compared to the control group. Total cholesterol, triglyceride and low density lipoprotein cholesterol were significantly reduced compared to the control while a significant increase in high density lipoprotein was observed in the treatment groups. The serum biochemical protein components were comparable to the control. The result of the haematological study revealed that mean cell volume, haemoglobin and packed cell volume levels were significantly increased in most of the treated groups compared to the control group. There were no features of acute or chronic damage by the extracts on the hepatic and renal tissues. The in vivo antibacterial effect of the extracts revealed decrease in total bacteria load in treated rats. Therefore, H. annus seeds extracts possess antibacterial effects against Salmonella spp and E.coli and is considered to be relatively safe. Further studies should be carried out to identify the exact active compound or compounds that possess bactericidal activity. There is need to establish the validity and mechanism of action of the hepato-protectiveeffect of H.annuus seed extracts inferred in this study





Related Project Materials

A critical assessment of leadership effectiveness in managing remote teams in Zenith Bank Plc, Benue State

Background of the Study
The increasing shift towards remote work, accelerated by the COVID-19 pandemic, has transformed org...

Read more
Design of an IoT Based Smart E Payment System for Secondary School Fees Collection in Lafia LGA, Nasarawa State

Background of the study
Efficient fee collection is essential for the smooth operation of educational institutions. In Laf...

Read more
An evaluation of the influence of money politics on election credibility in Jibia Local Government Area, Katsina State

Background of the Study
Money politics, where political candidates or parties use financial incentives to influence voters...

Read more
Design of AI-Based Student Well-being and Mental Health Monitoring Systems in Bama LGA, Borno State

Background of the Study

Mental health issues among students in higher education have become increasingly prominent, with rising concerns...

Read more
ASSESSMENT OF THE PHARMACOLOGICAL INTERVENTIONS IN PREVENTION OF MOTHER TO CHILD TRANSMISSION (PMTCT) OF HIV/AIDS IN NASARA TREATMENT AND CARE CENTRE, AHMADU BELLO UNIVERSITY TEACHING HOSPITAL, ZARIA-NIGERIA

ABSTRACT

This study was undertaken in Nasara Treatment and Care Centre ABUTH Zaria, to assess the effect of pharmacological interventions...

Read more
The Effect of Real-Time Stock Monitoring on Retail Supply Chain Efficiency: A Study of Supermarkets in Kaduna State

Background of the Study

Real-time stock monitoring (RTSM) has emerged as a critical to...

Read more
An Examination of the Link Between Career Development and Employee Commitment: A Case Study of Flour Mills in Benue State

Background of the Study

Career development refers to the structured efforts to provide employees with opportunities to g...

Read more
ASSESSMENT OF INNOVATIONS IN ASSESSING PRACTICAL SKILLS IN VOCATIONAL EDUCATION

ABSTRACT: Innovations in Assessing Practical Skills in Vocational Education address the need for more effective and accurate methods of evaluating...

Read more
The Role of Public Sector Accounting in Monitoring Student Loan Disbursements in Nigeria: A Case Study of the Nigeria Education Bank

Background of the Study

Student loans are an essential form of financial support for students pursuing...

Read more
The Effect of Legal Frameworks on Tax Dispute Outcomes: A Study of the Nigerian Tax Court System

Background of the Study

The Nigerian Tax Court system plays a pivotal role in resolvin...

Read more
Share this page with your friends




whatsapp